Invention Grant
- Patent Title: Rationally designed, synthetic antibody libraries and uses therefor
- Patent Title (中): 合理设计的合成抗体文库及其用途
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Application No.: US12404059Application Date: 2009-03-13
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Publication No.: US08877688B2Publication Date: 2014-11-04
- Inventor: Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
- Applicant: Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
- Applicant Address: US NH Lebanon
- Assignee: Adimab, LLC
- Current Assignee: Adimab, LLC
- Current Assignee Address: US NH Lebanon
- Agency: Choate, Hall & Stewart LLP
- Main IPC: C40B40/08
- IPC: C40B40/08
Abstract:
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
Public/Granted literature
- US20100056386A1 Rationally Designed, Synthetic Antibody Libraries and Uses Therefor Public/Granted day:2010-03-04
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