Invention Grant
US08877733B2 1′-substituted pyrimidine N-nucleoside analogs for antiviral treatment
有权
1'-取代的嘧啶N-核苷类似物用于抗病毒治疗
- Patent Title: 1′-substituted pyrimidine N-nucleoside analogs for antiviral treatment
- Patent Title (中): 1'-取代的嘧啶N-核苷类似物用于抗病毒治疗
-
Application No.: US13447017Application Date: 2012-04-13
-
Publication No.: US08877733B2Publication Date: 2014-11-04
- Inventor: Aesop Cho , Choung U. Kim , Thorsten A. Kirschberg , Michael R. Mish , Neil Squires
- Applicant: Aesop Cho , Choung U. Kim , Thorsten A. Kirschberg , Michael R. Mish , Neil Squires
- Applicant Address: US CA Foster City
- Assignee: Gilead Sciences, Inc.
- Current Assignee: Gilead Sciences, Inc.
- Current Assignee Address: US CA Foster City
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H19/06 ; A61K31/196 ; C07H19/073 ; A61K31/7068 ; C07H19/067 ; A61K31/7072 ; C07H19/09 ; C07H19/10 ; A61K45/06 ; A61K31/351 ; A61K31/245 ; C07H19/11 ; A61K38/21 ; A61K31/13
Abstract:
Provided are compounds of Formula I: nucleosides, nucleoside phosphates and prodrugs thereof, wherein R6 is CN, ethenyl, 2-haloethen-1-yl, or (C2-C8)-alkyn-1-yl. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.
Public/Granted literature
- US20120263678A1 1'-SUBSTITUTED PYRIMIDINE N-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT Public/Granted day:2012-10-18
Information query
