Invention Grant
- Patent Title: 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors
- Patent Title (中): 作为BACE1和/或BACE2抑制剂的1,4-氧氮杂
-
Application No.: US13432003Application Date: 2012-03-28
-
Publication No.: US08877744B2Publication Date: 2014-11-04
- Inventor: Robert Narquizian , Thomas Woltering , Wolfgang Wostl
- Applicant: Robert Narquizian , Thomas Woltering , Wolfgang Wostl
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Priority: EP11161044 20110404
- Main IPC: A61K31/553
- IPC: A61K31/553 ; C07D267/10 ; C07D413/10 ; C07D413/14 ; C07D417/10
Abstract:
The present invention relates to 1,4 Oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
Public/Granted literature
- US20120253035A1 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS Public/Granted day:2012-10-04
Information query
IPC分类:
