Invention Grant
US08877753B2 1-aryl-3-aminoalkoxy pyrazoles as sigma ligands enhancing analgesic effect of opioids and attenuating the dependency thereof
有权
1-芳基-3-氨基烷氧基吡唑作为西格玛配体增强阿片样物质的镇痛作用并减弱其依赖性
- Patent Title: 1-aryl-3-aminoalkoxy pyrazoles as sigma ligands enhancing analgesic effect of opioids and attenuating the dependency thereof
- Patent Title (中): 1-芳基-3-氨基烷氧基吡唑作为西格玛配体增强阿片样物质的镇痛作用并减弱其依赖性
-
Application No.: US12988951Application Date: 2009-04-24
-
Publication No.: US08877753B2Publication Date: 2014-11-04
- Inventor: Helmut Heinrich Buschmann , Jose Miguel Vela Hernandez , Daniel Zamanillo-Castanedo
- Applicant: Helmut Heinrich Buschmann , Jose Miguel Vela Hernandez , Daniel Zamanillo-Castanedo
- Applicant Address: ES Barcelona
- Assignee: Laboratorios Del Dr. Esteve, S.A.
- Current Assignee: Laboratorios Del Dr. Esteve, S.A.
- Current Assignee Address: ES Barcelona
- Agency: Hoffmann & Baron LLP
- Priority: EP08380122 20080425
- International Application: PCT/EP2009/054974 WO 20090424
- International Announcement: WO2009/130310 WO 20091029
- Main IPC: A61K31/4152
- IPC: A61K31/4152 ; A61K31/4155 ; A61K31/485 ; A61K31/5377 ; A61P25/36 ; C07D231/22 ; C07D401/12 ; C07D403/12 ; C07D471/04 ; A61K45/06
Abstract:
The invention relates to the use of a group of sigma receptor ligands of formula (I) for the potentiation of the analgesic effect of opioids and opiates and at the same time for decreasing the dependency induced by them.
Public/Granted literature
Information query
IPC分类:
