Invention Grant
US08877776B2 (L)-malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
有权
（4 - {[6,7-双（甲氧基）喹啉-4-基]氧基}苯基）-N' - （4-氟苯基）环丙烷-1,1-二甲酰胺的（L） - 苹果酸盐
![(L)-malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide](/docs/US/2014-11-04/US08877776B2/abs.jpg.600x600.jpg)
- Patent Title: (L)-malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
- Patent Title (中): （4 - {[6,7-双（甲氧基）喹啉-4-基]氧基}苯基）-N' - （4-氟苯基）环丙烷-1,1-二甲酰胺的（L） - 苹果酸盐
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Application No.: US13145054Application Date: 2010-01-15
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Publication No.: US08877776B2Publication Date: 2014-11-04
- Inventor: Adrian St. Clair Brown , Peter Lamb , William P. Gallagher
- Applicant: Adrian St. Clair Brown , Peter Lamb , William P. Gallagher
- Applicant Address: US CA South San Francisco
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Honigman Miller Schwartz & Cohn
- Agent Heidi M Berven; Jonathan P. O'Brien
- International Application: PCT/US2010/021194 WO 20100115
- International Announcement: WO2010/083414 WO 20100722
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/47 ; C07D215/00 ; C07D215/12 ; C07D215/16 ; C07D215/10
![(L)-malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide](/abs-image/US/2014/11/04/US08877776B2/abs.jpg.150x150.jpg)
Abstract:
Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane -1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate salt, and mixtures thereof; and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)-cyclopropane-1,1-dicarboxamide; and methods of treating cancer comprising administering at least one malate salt of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-ffuorophenyl)cyclopropane-1,1-dicarboxamide.
Public/Granted literature
- US20120035212A1 (L)-Malate salt of N-(4-phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Public/Granted day:2012-02-09
Information query
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