Invention Grant
- Patent Title: Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
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Application No.: US14093956Application Date: 2013-12-02
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Publication No.: US08877786B2Publication Date: 2014-11-04
- Inventor: Yuki Iwaki , Toshio Kawanami , Gary Michael Ksander , Muneto Moji
- Applicant: Yuki Iwaki , Toshio Kawanami , Gary Michael Ksander , Muneto Moji
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: Sophie Binet-Cross
- Main IPC: A61K31/41
- IPC: A61K31/41 ; A61K31/42 ; C07D257/06 ; C07D261/14 ; C07D231/40 ; A61K45/00
Abstract:
The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Public/Granted literature
- US20140088165A1 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors Public/Granted day:2014-03-27
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