Invention Grant
- Patent Title: Inhibitors of pyruvate kinase and methods of treating disease
- Patent Title (中): 丙酮酸激酶的抑制剂和治疗疾病的方法
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Application No.: US12376285Application Date: 2007-08-06
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Publication No.: US08877791B2Publication Date: 2014-11-04
- Inventor: Lewis Cantley , Matthew G. Vander Heiden , Heather R. Christofk
- Applicant: Lewis Cantley , Matthew G. Vander Heiden , Heather R. Christofk
- Applicant Address: US MA Boston
- Assignee: Beth Israel Deaconess Medical Center, Inc.
- Current Assignee: Beth Israel Deaconess Medical Center, Inc.
- Current Assignee Address: US MA Boston
- Agency: Clark & Elbing LLP
- Agent Kristina Bieker-Brady
- International Application: PCT/US2007/017519 WO 20070806
- International Announcement: WO2008/019139 WO 20080214
- Main IPC: A61K31/00
- IPC: A61K31/00 ; A61K31/381 ; A61K31/4184 ; A61K31/402 ; A61K31/426
Abstract:
The invention provides pharmaceutical compositions, kits, and methods of treating cancer, diabetes, obesity, autoimmune disease, and benign prostatic hyperplasia using compounds that selectively inhibit pyruvate kinase M2 and an assay measuring chemical modulation of pyruvate kinase activity.
Public/Granted literature
- US20100099726A1 INHIBITORS OF PYRUVATE KINASE AND METHODS OF TREATING DISEASE Public/Granted day:2010-04-22
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