Invention Grant
- Patent Title: Inorganic salt complexes of vildagliptin
- Patent Title (中): 维格列汀的无机盐配合物
-
Application No.: US13500356Application Date: 2010-10-07
-
Publication No.: US08877799B2Publication Date: 2014-11-04
- Inventor: Andras Mravik , Imre Koehegyi , Laszlo Pongo , Balazs Volk , Gabor Nemeth , Jozsef Barkoczy , Kalman Nagy , Gyoergy Ruzsics , Judit Broda , Andras Dancso , Adrienn Keszthelyi , Jozsef Debreczeni
- Applicant: Andras Mravik , Imre Koehegyi , Laszlo Pongo , Balazs Volk , Gabor Nemeth , Jozsef Barkoczy , Kalman Nagy , Gyoergy Ruzsics , Judit Broda , Andras Dancso , Adrienn Keszthelyi , Jozsef Debreczeni
- Applicant Address: HU Budapest
- Assignee: Egis Gyogyszergynar Nyilvanosan Muekoedoe Reszvenytarsasag
- Current Assignee: Egis Gyogyszergynar Nyilvanosan Muekoedoe Reszvenytarsasag
- Current Assignee Address: HU Budapest
- Agency: Lucas & Mercanti, LLP
- Agent Jonathan Myers
- Priority: HU0900638 20091007
- International Application: PCT/HU2010/000106 WO 20101007
- International Announcement: WO2011/042765 WO 20110414
- Main IPC: C07D207/16
- IPC: C07D207/16

Abstract:
The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further objects of the present invention are pharmaceutically acceptable complexes of vildagliptin and/or amorphous and crystalline forms, anhydrous forms, amorphous and crystalline hydrates, amorphous and crystalline solvates of the complexes and a process for the preparation thereof. Another object of the present invention is the high purity vildagliptin and pharmaceutically acceptable salts thereof prepared form the vildagliptin complexes of the present invention, a process for the preparation thereof and pharmaceutical compositions containing vildagliptin base, pharmaceutically acceptable salts and/or complexes and use thereof for the treatment of type 2 diabetes (NIDDM). The present invention provides pharmaceutically advantageous high purity vildagliptin complexes.
Public/Granted literature
- US20130005790A1 INORGANIC SALT COMPLEXES OF VILDAGLIPTIN Public/Granted day:2013-01-03
Information query