Invention Grant
- Patent Title: Glycoconjugates of RNA interference agents
- Patent Title (中): RNA干扰剂的糖缀合物
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Application No.: US12108253Application Date: 2008-04-23
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Publication No.: US08877917B2Publication Date: 2014-11-04
- Inventor: Andrea Forst , Philipp Hadwiger , Hans-Peter Vornlocher
- Applicant: Andrea Forst , Philipp Hadwiger , Hans-Peter Vornlocher
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: LeClairRyan
- Agent Jeffrey N. Townes
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K47/48 ; C12N15/113 ; C12N15/11
Abstract:
The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications.
Public/Granted literature
- US20090203135A1 Glycoconjugates of RNA Interference Agents Public/Granted day:2009-08-13
Information query
