Invention Grant
US08877944B2 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides as PARP inhibitors
有权
3-氧代-2,3-二氢-1H-异吲哚-4-甲酰胺作为PARP抑制剂
- Patent Title: 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides as PARP inhibitors
- Patent Title (中): 3-氧代-2,3-二氢-1H-异吲哚-4-甲酰胺作为PARP抑制剂
-
Application No.: US13383606Application Date: 2010-07-06
-
Publication No.: US08877944B2Publication Date: 2014-11-04
- Inventor: Gianluca Mariano Enrico Papeo , Alina Anatolievna Busel , Alexander Khvat , Mikhail Yurievitch Krasavin , Barbara Forte , Fabio Zuccotto
- Applicant: Gianluca Mariano Enrico Papeo , Alina Anatolievna Busel , Alexander Khvat , Mikhail Yurievitch Krasavin , Barbara Forte , Fabio Zuccotto
- Applicant Address: IT Nerviano (MI)
- Assignee: Nerviano Medical Sciences S.R.L.
- Current Assignee: Nerviano Medical Sciences S.R.L.
- Current Assignee Address: IT Nerviano (MI)
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP09165443 20090714; EP10159776 20100413
- International Application: PCT/EP2010/059607 WO 20100706
- International Announcement: WO2011/006794 WO 20110120
- Main IPC: A61K31/40
- IPC: A61K31/40 ; C07D209/44 ; C07D401/14 ; C07D409/14 ; C07D401/04 ; C07D405/14 ; C07D209/46 ; C07D417/14
Abstract:
There are provided substituted 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide derivatives (I) which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating, diseases utilizing pharmaceutical compositions comprising these compounds.
Public/Granted literature
- US20120245142A1 3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES AS PARP INHIBITORS Public/Granted day:2012-09-27
Information query
