Various embodiments for replicating deduplicated data using a processor device are provided. A block of the deduplicated data, created in a source repository, is assigned a global block identifier (ID) unique in a grid set inclusive of the source repository. The global block ID is generated using at least one unique identification value of the block, a containing grid of the grid set, and the source repository. The global block ID is transmitted from the source repository to a target repository. If the target repository determines the global block ID is associated with an existing block of the deduplicated data located within the target repository, the block is not transmitted to the target repository during a subsequent replication process.