A method and a system for processing an HTTP request. There is provided a method for processing an HTTP request, including: receiving an original HTTP request for accessing an instance of an application; modifying a domain name to be accessed; and sending the new HTTP request to a server of the application so as to access the instance of the application, wherein the domain name to be accessed by the original HTTP request and the new domain name correspond to a same IP address. This avoids various problems such as data confusion, data error, and use inconvenience in the related art occurring when a plurality of service instances of a same application run in a same hypertext transfer protocol session. A system for carrying out the above method is also provided.