A wake-and-go mechanism is provided for a data processing system. The wake-and-go mechanism recognizes a programming idiom that indicates that a thread is spinning on a lock. The wake-and-go mechanism updates a wake-and-go array with a target address associated with the lock and sets a lock bit in the wake-and-go array. The thread then goes to sleep until the lock frees. The wake-and-go array may be a content addressable memory (CAM). When a transaction appears on the symmetric multiprocessing (SMP) fabric that modifies the value at a target address in the CAM, the CAM returns a list of storage addresses at which the target address is stored. The wake-and-go mechanism associates these storage addresses with the threads waiting for an event at the target addresses, and may wake the thread that is spinning on the lock.