Methods and systems for content filtering of remote file-system access protocols are provided. According to one embodiment, a remote file-system access protocol request issued by a client to a server is received at a network device logically interposed between the client and the server. The request is issued to the server by the network device. A single shared holding buffer, used for both read and write accesses to the file and used by multiple processes running on the client, is implemented by the network device for the file during a remote file-system access protocol session. Data being read from or written to the file as a result of the request is buffered into the buffer. Responsive to a predetermined event in relation to the remote file-system access protocol or the buffer, the existence or non-existence of malicious, dangerous or unauthorized content is determined by performing content filtering on the buffer.