A system and method for use with a device that includes an accelerometer, which can be used to determine a frame of reference for the device relative to a moving vehicle or other equipment, and which can be subsequently used in assessing or monitoring the status of the vehicle or an operator thereof. In accordance with an embodiment, by sampling accelerometer data over a period of time, the system can determine a rotation matrix or skew between the device/accelerometer's orientation and understanding of direction, and the vehicle's true orientation or direction in three-dimensions. The information can be used to provide corrections to the accelerometer data, and to more accurately determine the vehicle's true orientation/direction and motion within a three-dimensional frame of reference.