A method for operating an automation system with a plurality of communication users linked for communication purposes via a serial connection, of which at least one functions as sender and at least one as a receiver, includes determining at a sender an offset value between an occurrence of a synchronous signal and a communication clock cycle, transmitting the determined offset value in a data transmission to the at least one receiver, waiting at the at least one receiver until a time period commensurate with the offset value has elapsed, and generating at the at least one receiver an output signal after the time period has elapsed.