A spindle drive having a threaded spindle driveable in a rotational fashion, a carriage adjustable via the threaded spindle along a guide rail, and several guide carriages arranged in front and behind the carriage in the feed direction to support the spindle, with the guide carriages arranged in front of the carriage in an accumulating motion being pushed together successively by the carriage towards the spindle end, and with the guide carriages arranged behind the carriage being entrained by a coupling mechanism and moved into allocated support positions. Coupling elements are provided on the guide carriages and the carriage, that cooperate together and can be operated by switching elements fixed on the guide rail, by which the guide carriages arranged in front of the carriage are automatically coupled during the successive displacement motion, and by which the entrained guide carriages upon reaching their support position are automatically decoupled and fixed.