Isolation systems for use in a wellbore include two or more tubular segments and at least one coupling assembly. The at least one coupling system is adapted to couple the first and second tubular segments together. The at least one coupling system is further adapted to block at least a portion of the wellbore annulus. The at least one coupling system is further configured as a leaky isolation assembly to separate the wellbore annulus into at least two isolated zones when disposed in the wellbore. At least one isolation zone has at least two outlets including a first outlet through an opening into the tubular and a second outlet past the leaky isolation assembly. The isolation system is configured to provide the isolation with hydraulics during well operation that preferentially drives fluids through the first outlet and at least substantially prevents fluid from passing the isolation assembly.