A bicycle frame with removable dropouts includes a bicycle frame having a left seat stay and a left chain stay joined at a left junction, and a right seat stay and a right chain stay joined at a right junction. A left dropout is removably connected to the bicycle frame at the left junction, the left dropout including a body defining an opening for receiving a rear wheel. A right dropout is removably connected to the bicycle frame at the right junction, the right dropout including a body defining an opening for receiving the rear wheel.