There is provided an optical engine assembly including an active unit and a transmission unit. The active unit includes a first bearing member configured to carry an optoelectronic unit. The transmission unit includes a second bearing member configured to fix a plurality of optical waveguides. The optoelectronic unit is optically coupled to the optical waveguides. The first bearing member and the second bearing member have symmetrical structures. The present disclosure further provides a manufacturing method of an optical engine assembly.