Invention Grant
US08900586B2 Antibody that binds domain 2 of ICAM-1 and methods of treatment
有权
结合ICAM-1的结构域2的抗体及其治疗方法
- Patent Title: Antibody that binds domain 2 of ICAM-1 and methods of treatment
- Patent Title (中): 结合ICAM-1的结构域2的抗体及其治疗方法
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Application No.: US14128815Application Date: 2011-07-05
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Publication No.: US08900586B2Publication Date: 2014-12-02
- Inventor: Seong Hoe Park , Kyeong Cheon Jung
- Applicant: Seong Hoe Park , Kyeong Cheon Jung
- Applicant Address: KR Seoul KR Seoul
- Assignee: Dinona Inc.,SNU R&DB Foundation
- Current Assignee: Dinona Inc.,SNU R&DB Foundation
- Current Assignee Address: KR Seoul KR Seoul
- Agency: Lexyoume IP Meister, PLLC
- International Application: PCT/KR2011/004908 WO 20110705
- International Announcement: WO2013/005873 WO 20130110
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C12N5/12 ; C07K16/00 ; C12N5/16
Abstract:
The present invention relates to an antibody binding to the domain 2 of human intercellular adhesion molecules-1 (ICAM-1) where the antibody is able to modulate the differentiation status of dendritic cells and induce antigen-specific T cell tolerance, thereby be effective in the prevention and/or treatment of T cell-mediated immune disorders such as transplantation rejection, graft-versus-host disease, and autoimmune disease. In addition, the present invention provides a pharmaceutical composition comprising the antibody, and method of using them for the treatment of disease.
Public/Granted literature
- US20140148583A1 ANTIBODY INDUCING ANTIGEN-SPECIFIC T CELL TOLERANCE AND USE THEREOF Public/Granted day:2014-05-29
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