Invention Grant
- Patent Title: Selective glycosidase inhibitors and uses thereof
- Patent Title (中): 选择性糖苷酶抑制剂及其用途
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Application No.: US13883811Application Date: 2011-11-08
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Publication No.: US08901087B2Publication Date: 2014-12-02
- Inventor: Jiang Chang , Kun Liu , Ernest J. McEachern , Changwei Mu , Harold G. Selnick , Feng Shi , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou , Yongbao Zhu
- Applicant: Jiang Chang , Kun Liu , Ernest J. McEachern , Changwei Mu , Harold G. Selnick , Feng Shi , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou , Yongbao Zhu
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent J. Eric Thies; John C. Todaro
- Priority: WOPCT/CN2010/078528 20101108; WOPCT/CN2011/008069 20111012
- International Application: PCT/US2011/059668 WO 20111108
- International Announcement: WO2012/064680 WO 20120518
- Main IPC: C08B37/00
- IPC: C08B37/00 ; C07D487/02 ; A61K31/70 ; A61K31/425 ; C07D513/04
Abstract:
The invention is directed to compounds for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds, and methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, and/or accumulation or deficiency of O-GlcNAc.
Public/Granted literature
- US20130296301A1 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2013-11-07
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