Invention Grant
US08901123B2 Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
有权
2-氟-N-甲基-4- [7-（喹啉-6-基 - 甲基） - 咪唑并[1,2-B] [1,2,4]三嗪-2-基]苯甲酰胺的盐和相关的方法 准备相同
![Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same](/docs/US/2014-12-02/US08901123B2/abs.jpg.600x600.jpg)
- Patent Title: Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
- Patent Title (中): 2-氟-N-甲基-4- [7-（喹啉-6-基 - 甲基） - 咪唑并[1,2-B] [1,2,4]三嗪-2-基]苯甲酰胺的盐和相关的方法 准备相同
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Application No.: US13793864Application Date: 2013-03-11
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Publication No.: US08901123B2Publication Date: 2014-12-02
- Inventor: Lingkai Weng , Lei Qiao , Jiacheng Zhou , Pingli Liu , Yongchun Pan
- Applicant: Lingkai Weng , Lei Qiao , Jiacheng Zhou , Pingli Liu , Yongchun Pan
- Applicant Address: US DE Wilmington
- Assignee: Incyte Corporation
- Current Assignee: Incyte Corporation
- Current Assignee Address: US DE Wilmington
- Agency: Lathrop & Gage LLP
- Agent Brian C. Trinque
- Main IPC: A01N43/64
- IPC: A01N43/64 ; A61K31/53 ; C07D487/00
![Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-B][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same](/abs-image/US/2014/12/02/US08901123B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.
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