Invention Grant
US08901129B2 Methods of facilitating neural cell survival using GDNF family ligand (GFL) mimetics or RET signaling pathway activators
有权
使用GDNF家族配体（GFL）模拟物或RET信号通路激活剂促进神经细胞存活的方法
- Patent Title: Methods of facilitating neural cell survival using GDNF family ligand (GFL) mimetics or RET signaling pathway activators
- Patent Title (中): 使用GDNF家族配体（GFL）模拟物或RET信号通路激活剂促进神经细胞存活的方法
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Application No.: US13514906Application Date: 2010-12-13
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Publication No.: US08901129B2Publication Date: 2014-12-02
- Inventor: Mart Saarma , Mati Karelson , Maxim Bespalov , Mehis Pilv
- Applicant: Mart Saarma , Mati Karelson , Maxim Bespalov , Mehis Pilv
- Applicant Address: EE Tallinn
- Assignee: GeneCode AS
- Current Assignee: GeneCode AS
- Current Assignee Address: EE Tallinn
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/EP2010/069535 WO 20101213
- International Announcement: WO2011/070177 WO 20110616
- Main IPC: A61K31/496
- IPC: A61K31/496 ; C07D241/04 ; C07D295/192 ; C07D215/46 ; C07D285/135 ; C07D513/10 ; C07D219/10 ; C07D263/57
Abstract:
Disclosed are compounds and methods for treating neurological and other disorders by administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for GFRα receptor molecules, which can be mimetics of glial-derived neurotrophic factor (GDNF) family ligands (GFLs), GFRα/RET signaling pathway agonists, and/or direct RET agonists (activators).
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