Invention Grant
US08901137B2 Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K and mTOR in combination with autophagy inhibitors
有权
使用PI3K和mTOR的吡啶并嘧啶酮抑制剂与自噬抑制剂联合治疗癌症的方法
- Patent Title: Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K and mTOR in combination with autophagy inhibitors
- Patent Title (中): 使用PI3K和mTOR的吡啶并嘧啶酮抑制剂与自噬抑制剂联合治疗癌症的方法
-
Application No.: US13578058Application Date: 2011-02-09
-
Publication No.: US08901137B2Publication Date: 2014-12-02
- Inventor: Dana T. Aftab , Wolfgang M. Korn , Olga K. Mirzoeva
- Applicant: Dana T. Aftab , Wolfgang M. Korn , Olga K. Mirzoeva
- Applicant Address: US CA South San Francisco
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Heidi M. Berven; Jonathan P. O'Brien
- International Application: PCT/US2011/024187 WO 20110209
- International Announcement: WO2011/100319 WO 20110818
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519 ; A61K31/4706 ; A61K35/00 ; A61K45/06
Abstract:
The invention provides compounds of Formula I: that inhibit the PI3Ks and mTOR that are useful in the treatment of cancer in humans when used in combination with autophagy inhibitors.
Public/Granted literature
Information query
IPC分类:
