Invention Grant
- Patent Title: Neprilysin inhibitors
- Patent Title (中): Neprilysin抑制剂
-
Application No.: US14196624Application Date: 2014-03-04
-
Publication No.: US08901169B2Publication Date: 2014-12-02
- Inventor: Erik Fenster , Melissa Fleury , Adam D. Hughes
- Applicant: Erik Fenster , Melissa Fleury , Adam D. Hughes
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: C07C235/74
- IPC: C07C235/74 ; A61K31/7048 ; C07C231/02 ; A61K31/24 ; C07D407/12 ; A61K31/365 ; A61K31/22 ; C07D317/40 ; A61K31/265 ; C07C243/28 ; C07C241/02 ; A61P9/12 ; A61P9/04 ; A61P13/12 ; A61K31/197 ; A61K31/44 ; C07D205/04 ; A61K31/5375 ; A61K31/397 ; C07D207/09 ; C07D491/107 ; C07C235/34 ; C07D261/04 ; C07D295/32 ; A61K31/40 ; C07D213/56 ; A61K31/42 ; C07D207/14
Abstract:
In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
Public/Granted literature
- US20140256702A1 NEPRILYSIN INHIBITORS Public/Granted day:2014-09-11
Information query
