Invention Grant
US08901297B2 Compositions for modulating a kinase cascade and methods of use thereof
有权
用于调节激酶级联的组合物及其使用方法
- Patent Title: Compositions for modulating a kinase cascade and methods of use thereof
- Patent Title (中): 用于调节激酶级联的组合物及其使用方法
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Application No.: US13614063Application Date: 2012-09-13
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Publication No.: US08901297B2Publication Date: 2014-12-02
- Inventor: David G. Hangauer, Jr. , Debasis Patra , Jeremy A. Cody , Grant J. Palmer , Paul K. Isbester , Jonathon Salsbury
- Applicant: David G. Hangauer, Jr. , Debasis Patra , Jeremy A. Cody , Grant J. Palmer , Paul K. Isbester , Jonathon Salsbury
- Applicant Address: US NY Buffalo
- Assignee: Kinex Pharmaceuticals, LLC
- Current Assignee: Kinex Pharmaceuticals, LLC
- Current Assignee Address: US NY Buffalo
- Agency: Cooley LLP
- Main IPC: C07D213/59
- IPC: C07D213/59 ; A61K31/44 ; C07D213/56 ; C07D413/12
Abstract:
The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning calorimetry profile, as well as a unique crystalline structure.
Public/Granted literature
- US20130210822A1 Compositions for Modulating a Kinase Cascade and Methods of Use Thereof Public/Granted day:2013-08-15
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