A networking enclosure with removable and interchangeable sides includes a housing with an internal cavity for receipt of electrical devices and first, second, and third openings. The enclosure also includes first, second, and third sets of panels corresponding to each of the openings. The first set of panels includes at least two panels with different configurations and being selectively engageable with the housing to substantially close the first opening. The second set of panels includes at least two panels with different configurations and being selectively engageable with the housing to substantially close the second opening. Similarly, the third set of panels includes at least two panels having different configurations and being selectively engageably with the housing to substantially close the third opening. The panels can be solid or include apertures such as knockouts, louvers, or a combination thereof.