Various technologies described herein pertain to defect pixel correction for image data collected by a pixel array of an image sensor with spatially arranged exposures. The pixel array includes a first subset of pixels having a first exposure time and a second subset of pixels having a second exposure time. An exposure ratio (ratio of first exposure time to second exposure time) is received. A value of at least a particular neighbor pixel of a given pixel from the image data is adjusted based upon the exposure ratio. Neighborhood statistics for the given pixel from the image data are computed based on values of neighbor pixels of the given pixel from the image data as adjusted. Whether the value of the given pixel is defective is detected based on the neighborhood statistics. The value of the given pixel is replaced when detected to be defective to output modified image data.