Methods, systems, and computer readable media for low power multimode interconnect for lossy and tightly coupled multi-channel are disclosed. According to one aspect, a system for low power multimode interconnect includes a receiver for receiving a plurality of input signals that have been encoded by a multimode encoding equation to have voltage levels according to the multimode encoding equation and for decoding the received signals according to a multimode decoding equation to produce binary data as output, wherein the receiver includes a set of frequency-compensated amplifiers for emphasizing high-frequency components of the received input signals and a set of latches for receiving amplified signals from the frequency-compensated amplifiers and for decoding the amplified signals according to the multimode decoding equation to produce binary data as output.