Systems and methods in accordance with embodiments of the invention operate a substitution hybrid game including: a gambling game; a multiplayer entertainment game that triggers at least one wager in the gambling game; a substitution module constructed to access a database containing player profiles associated with players of the substitution hybrid game, and the substitution module is constructed to: detect a substitution request from a human player via a user interface concerning a gameplay session of the substitution hybrid game, where a player profile within the database describes the human player; evaluate whether the substitution request involves a substitution of players that satisfies at least one substitution standard using at least the player profile that describes the human player; and perform the requested player substitution when the substitution request satisfies the at least one substitution standard.