Invention Grant
- Patent Title: Method for modulating double-strand break-induced homologous recombination
- Patent Title (中): 调节双链断裂诱导的同源重组的方法
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Application No.: US13695225Application Date: 2010-04-30
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Publication No.: US08906607B2Publication Date: 2014-12-09
- Inventor: Philippe Duchateau , Frédéric Paques , Christophe Perez-Michaut , Fabien Delacote
- Applicant: Philippe Duchateau , Frédéric Paques , Christophe Perez-Michaut , Fabien Delacote
- Applicant Address: FR Paris
- Assignee: Cellectis
- Current Assignee: Cellectis
- Current Assignee Address: FR Paris
- Agency: Law Office of Salvatore Arrigo and Scott Lee, LLP
- International Application: PCT/IB2010/001286 WO 20100430
- International Announcement: WO2011/135396 WO 20111103
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12N15/113 ; C12N15/11 ; C12N15/10

Abstract:
The present invention concerns a method for modulating double-strand break-induced homologous recombination through the identification of effectors that modulate said double-strand break-induced homologous recombination by uses of interfering agents; these agents are capable of modulating double-strand break-induced homologous recombination through their respective actions on said effectors. The present invention also concerns the uses of these effectors and interfering agents and derivatives, respectively, by introducing them in an eukaryotic cell in order to modulate and more particularly to increase double-strand break-induced homologous recombination and gene targeting efficiency. The present invention also relates to specific derivatives of identified effectors and interfering agents, vectors encoding them, compositions and kits comprising such derivatives in order to modulate and more particularly to increase double-strand break-induced homologous recombination and gene targeting efficiency.
Public/Granted literature
- US20130190385A1 METHOD FOR MODULATING DOUBLE-STRAND BREAK-INDUCED HOMOLOGOUS RECOMBINATION Public/Granted day:2013-07-25
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