Invention Grant
US08906615B2 2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use
有权
2'-阿拉伯 - 氟代寡核苷酸N 3'→P 5'氨基磷酸酯：它们的合成和用途
- Patent Title: 2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use
- Patent Title (中): 2'-阿拉伯 - 氟代寡核苷酸N 3'→P 5'氨基磷酸酯：它们的合成和用途
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Application No.: US13769090Application Date: 2013-02-15
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Publication No.: US08906615B2Publication Date: 2014-12-09
- Inventor: Sergei M. Gryaznov , Ronald G. Schultz
- Applicant: Geron Corporation
- Applicant Address: US CA Menlo Park
- Assignee: Geron Corporation
- Current Assignee: Geron Corporation
- Current Assignee Address: US CA Menlo Park
- Agent Leslie A. Mooi
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/53 ; C07H21/02
Abstract:
Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(═O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-aribino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.
Public/Granted literature
- US20130253034A1 2'-Arabino-Fluorooligonucleotide N3'-->P5' Phosphoramidates: Their Synthesis and Use Public/Granted day:2013-09-26
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