Invention Grant
US08906634B2 Monitoring and inhibiting human immunodeficiency virus infection by modulating HMGB1 dependent triggering of HIV-1 replication and persistence
有权
通过调节HMGB1依赖性触发HIV-1复制和持续性来监测和抑制人体免疫缺陷病毒感染
- Patent Title: Monitoring and inhibiting human immunodeficiency virus infection by modulating HMGB1 dependent triggering of HIV-1 replication and persistence
- Patent Title (中): 通过调节HMGB1依赖性触发HIV-1复制和持续性来监测和抑制人体免疫缺陷病毒感染
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Application No.: US13827722Application Date: 2013-03-14
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Publication No.: US08906634B2Publication Date: 2014-12-09
- Inventor: Marie-Lise Gougeon , Hela Saidi , Marie-Therese Melki , Beatrice Poirier-Beaudoin , Valerie Seffer
- Applicant: Institut Pasteur
- Applicant Address: FR Paris
- Assignee: Institut Pasteur
- Current Assignee: Institut Pasteur
- Current Assignee Address: FR Paris
- Agency: Law Office of Salvatore Arrigo and Scott Lee, LLP
- Main IPC: G01N33/569
- IPC: G01N33/569 ; A61K31/00 ; A61K31/704
Abstract:
Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.
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