Invention Grant
- Patent Title: Optically active dibenzylamine derivative, and method for preparing thereof
- Patent Title (中): 光活性二苄胺衍生物及其制备方法
-
Application No.: US13700849Application Date: 2011-06-03
-
Publication No.: US08906895B2Publication Date: 2014-12-09
- Inventor: Tadaaki Ohgiya , Takeshi Murakami , Katsutoshi Miyosawa , Kimiyuki Shibuya , Koichi Yamazaki , Taichi Kusakabe
- Applicant: Tadaaki Ohgiya , Takeshi Murakami , Katsutoshi Miyosawa , Kimiyuki Shibuya , Koichi Yamazaki , Taichi Kusakabe
- Applicant Address: JP Aichi
- Assignee: Kowa Company, Ltd.
- Current Assignee: Kowa Company, Ltd.
- Current Assignee Address: JP Aichi
- Agency: Greenblum & Bernstein, P.L.C.
- Priority: JP2010-128585 20100604; JP2010-218299 20100929
- International Application: PCT/JP2011/062751 WO 20110603
- International Announcement: WO2011/152508 WO 20111208
- Main IPC: A61K31/495
- IPC: A61K31/495 ; C07D239/48 ; C07D239/47
Abstract:
Substantially optically pure (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, or a salt thereof, or a solvate thereof, which has actions of reducing amount of PCSK9 protein and increasing amount of LDL receptor.
Public/Granted literature
- US20130225814A1 OPTICALLY ACTIVE DIBENZYLAMINE DERIVATIVE, AND METHOD FOR PREPARING THEREOF Public/Granted day:2013-08-29
Information query
