Invention Grant
- Patent Title: Ethylene diamine modulators of fatty acid hydrolase
- Patent Title (中): 脂肪酸水解酶的乙二胺调节剂
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Application No.: US13390984Application Date: 2010-08-17
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Publication No.: US08906914B2Publication Date: 2014-12-09
- Inventor: Natalie A. Hawryluk , J. Guy Breitenbucher , William M. Jones , Alison L. Chambers , John M. Keith , Mark Seierstad
- Applicant: Natalie A. Hawryluk , J. Guy Breitenbucher , William M. Jones , Alison L. Chambers , John M. Keith , Mark Seierstad
- Applicant Address: BE
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE
- Agent Mary A. Appollina
- International Application: PCT/US2010/045683 WO 20100817
- International Announcement: WO2011/022348 WO 20110224
- Main IPC: C07D239/42
- IPC: C07D239/42 ; C07D403/12 ; A61K31/506 ; C07D417/12 ; C07D413/04 ; C07D409/12 ; C07D409/04 ; C07D401/04 ; C07D413/12 ; C07D405/12 ; C07D405/04

Abstract:
Certain ethylene diamine compounds of Formula (I) are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.
Public/Granted literature
- US20120149696A1 ETHYLENE DIAMINE MODULATORS OF FATTY ACID HYDROLASE Public/Granted day:2012-06-14
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