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US08907087B2 Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors 有权
取代的吡嗪并[2,3-b]吡嗪作为mTOR激酶抑制剂

Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors
Abstract:
Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof. Furthermore, provided are methods of preparing a compound of formula (III), Furthermore, provided are methods of preparing a compound of formula (VI),
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