A method and interface for serial communication is provided. The interface includes a differential input/output having a first node and a second node. There are several input/output nodes arranged to receive serial interface signals. The interface includes a transmitter configured to drive a twisted pair cable at the differential input/output. There is a receiver coupled to the differential input/output that includes a window comparator. A serial port control unit provides serial data to the transmitter and receives serial data from the receiver. The serial communications interface transmits serial data to and receives serial data from a second serial communications interface independent of a reference clock and is galvanically isolated from the second serial communications interface.