Provided are a method and an apparatus for signal transmission in a wireless communication system. The apparatus comprises: an information processor for generating a first information sequence based on a first transmission symbol and a first resource index, and a second information sequence based on a second transmission symbol and a second resource index; a reference signal generator for generating a different reference signal depending upon whether a first resource block indicated by the first resource index and a second resource block indicated by the second resource index are the same; and an antenna for transmitting a signal generated based on the first information sequence, the second information sequence, and the reference signal sequence.