Interfaces and other systems are provided to receive input corresponding to anatomical elements. The anatomical elements are rendered on the interfaces or other systems with visual, audio and/or haptic feedback. Simulations of the anatomical elements can reflect the impact of existing and anticipated conditions. Personalized conditions and other data can also be used to modify and personalize the simulations and other output. Various controls are provided by the interfaces and systems to access and modify settings associated with personalized and generalized condition input data. Some simulations incorporate real-time data to mimic personalized anatomical elements.