Isolation techniques for multiple co-located radio modules are disclosed. For example, an apparatus may include an antenna, a first transceiver to communicate wirelessly across a first link, a second transceiver to communicate wirelessly across a second link, a shared antenna structure operative to allow the first transceiver and the second transceiver to share the antenna for simultaneous operations, and an active signal canceller operative to generate a cancellation signal to cancel an interference signal for a radio-frequency coupling channel between the first and second transceivers. Other embodiments are disclosed and claimed.