What is disclosed is a frame management function defined for a machine architecture of a computer system. In one embodiment, a frame management instruction is obtained which identifies a first and second general register. The first general register contains a frame management field having a key field with access-protection bits and a block-size indication. If the block-size indication indicates a large block then an operand address of a large block of data is obtained from the second general register. The large block of data has a plurality of small blocks each of which is associated with a corresponding storage key having a plurality of storage key access-protection bits. If the block size indication indicates a large block, the storage key access-protection bits of each corresponding storage key of each small block within the large block is set with the access-protection bits of the key field.