Systems and methods for setting up VPN connection are provided. Method includes facilitating creating gateway connection between client side and server side. Client side comprises multiple client side virtual NICs and server side comprises multiple server side virtual NICs. Method includes facilitating creating data paths for VPN connection between each of at least portion of client side virtual NICs and each of at least portion of server side virtual NICs. Data path of each pair of corresponding client side virtual NICs and corresponding server side virtual NIC is associated with gateway connection and port forward. Method includes facilitating transmitting data, via first data path for VPN connection, between first client computing device communicatively coupled with corresponding client side virtual NIC of first data path and first server computing device communicatively coupled with corresponding server side virtual NIC of first data path.