Invention Grant
US08912345B2 Method for preparing optically pure (−)-clausenamide compound
有权
制备光学纯（ - ） - 克劳森酰胺化合物的方法
- Patent Title: Method for preparing optically pure (−)-clausenamide compound
- Patent Title (中): 制备光学纯（ - ） - 克劳森酰胺化合物的方法
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Application No.: US14125055Application Date: 2011-11-04
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Publication No.: US08912345B2Publication Date: 2014-12-16
- Inventor: Yian Shi , Xianyou Peng , Peijun Li
- Applicant: Yian Shi , Xianyou Peng , Peijun Li
- Applicant Address: CN Beijing
- Assignee: Institute of Chemistry Chinese Academy of Sciences
- Current Assignee: Institute of Chemistry Chinese Academy of Sciences
- Current Assignee Address: CN Beijing
- Agency: Alleman Hall McCoy Russell & Tuttle LLP
- Priority: CN2011101551737 20110610
- International Application: PCT/CN2011/001868 WO 20111104
- International Announcement: WO2012/167413 WO 20121213
- Main IPC: C07D207/273
- IPC: C07D207/273
Abstract:
Disclosed in the present invention is a method for preparing a (−)-clausenamide compound of formula (I), comprising: firstly, catalyzing the asymmetrical epoxidation of trans-cinnamate using a chiral ketone derived from fructose or a hydrate thereof as a catalyst, and then subjecting the product to amidation, oxidation, cyclization and reduction successively to finally obtain the optically pure (−)-clausenamide compound of formula (I).
Public/Granted literature
- US20140200355A1 Method for Preparing Optically Pure (-)-Clausenamide Compound Public/Granted day:2014-07-17
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