Methods and systems for remediating a security policy violation on a computer system are provided. According to one embodiment, information regarding a program-code-based operational state of a computer system is periodically sampled. A determination is made regarding whether the program-code-based operational state represents a violation of a security policy by evaluating the information with respect to multiple security policies each of with defines at least one parameter condition violation of which is potentially indicative of unauthorized activity on the computer system or manipulation of the computer system to make the computer system vulnerable to attack. When a violation exists then a remediation is identified and deployed to the computer system. The violation is based at least in part on one or more of: whether a particular process is running; the existence, version or status of a particular application; and a version, type or configuration of an operating system installed.