Invention Grant
US08916517B2 Analogs of pituitary adenylate cyclase-activating polypeptide (PACAP) and methods for their use
有权
垂体腺苷酸环化酶活化多肽（PACAP）的类似物及其使用方法
- Patent Title: Analogs of pituitary adenylate cyclase-activating polypeptide (PACAP) and methods for their use
- Patent Title (中): 垂体腺苷酸环化酶活化多肽（PACAP）的类似物及其使用方法
-
Application No.: US13505370Application Date: 2010-11-02
-
Publication No.: US08916517B2Publication Date: 2014-12-23
- Inventor: David H. Coy , Jerome L. Maderdrut , Min Li
- Applicant: David H. Coy , Jerome L. Maderdrut , Min Li
- Applicant Address: US LA New Orleans
- Assignee: The Administrators of the Tulane Educational Fund
- Current Assignee: The Administrators of the Tulane Educational Fund
- Current Assignee Address: US LA New Orleans
- Agency: Clark & Elbing LLP
- Agent Paul T. Clark, Esq.; Todd Armstrong
- International Application: PCT/US2010/055164 WO 20101102
- International Announcement: WO2011/054001 WO 20110505
- Main IPC: A61K38/17
- IPC: A61K38/17 ; C07K14/435 ; A61P11/00 ; A61P13/12 ; A61P1/00 ; A61P27/02 ; A61P37/06 ; A61P9/00 ; A61P9/12 ; A61P35/00 ; A61P3/04 ; A61P3/10 ; A61K45/06 ; C07K14/575 ; A61K33/24 ; A61K38/00
Abstract:
This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1 and VPAC2 receptors. These PACAP analogs can be used as prophylactic/therapeutic agents for a wide range of medical disorders, including (but not limited to) cancer and autoimmune disease. These PACAP analogs can be coupled to suitable radionuclides and used in the localization, diagnosis and treatment of disseminated cancers and metastatic tumors, or coupled to small molecule therapeutics and used as vectors for targeted drug delivery. This invention also provides pharmaceutical compositions of one or more PACAP-like compounds of the invention either alone or in combination with one or more other prophylactic/therapeutic agents.
Public/Granted literature
- US20130065816A1 ANALOGS OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE Public/Granted day:2013-03-14
Information query
IPC分类:
