Invention Grant
US08916690B2 Growth-inhibited hydroxyapatite, process for its preparation and use
有权
生长抑制羟基磷灰石,其制备和使用过程
- Patent Title: Growth-inhibited hydroxyapatite, process for its preparation and use
- Patent Title (中): 生长抑制羟基磷灰石,其制备和使用过程
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Application No.: US13812497Application Date: 2011-08-04
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Publication No.: US08916690B2Publication Date: 2014-12-23
- Inventor: Sascha Heinemann , Christiane Heinemann , Hartmut Worch , Thomas Hanke , Wolfgang Pompe
- Applicant: Sascha Heinemann , Christiane Heinemann , Hartmut Worch , Thomas Hanke , Wolfgang Pompe
- Applicant Address: DE Dresden
- Assignee: Technische Universität Dresden
- Current Assignee: Technische Universität Dresden
- Current Assignee Address: DE Dresden
- Agent Gudrun E. Huckett
- Priority: DE102010038926 20100804
- International Application: PCT/EP2011/063470 WO 20110804
- International Announcement: WO2012/017045 WO 20120209
- Main IPC: C08H1/00
- IPC: C08H1/00 ; A61L27/44 ; A61L27/48 ; A61L27/12 ; C01B25/32 ; A61F2/28 ; A61L27/46 ; A61L27/24

Abstract:
The invention relates to growth-inhibited hydroxyapatite for improving bone healing. It differs from the apatites employed to date in that it releases calcium ions and phosphate ions in physiological solutions, which, unlike traditional hydroxyapatites, it does not bind. It thereby promotes bone regeneration and bone growth. The growth-inhibited hydroxyapatite contains in agglomerates of prestructured collagen templates on which hydroxyapatite crystals with a crystallite growth of below its critical nucleus radius are formed epitactically. It is prepared by the steps a) mineralization of prestructured collagen templates in supersaturated Ca- and phosphate-ion-containing solutions, where the prestructured collagen templates are capable of diffusion and/or migration, so that HAP crystallites grow epitactically on the collagen templates and the collagen templates grown together with HAP crystallites agglomerate due to their capability of diffusion and/or migration, b) separating off the agglomerates.
Public/Granted literature
- US20130122067A1 Growth-inhibited hydroxyapatite, process for its preparation and use Public/Granted day:2013-05-16
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