Invention Grant
- Patent Title: Monoconjugated chitosans as delivery agents for small interfering nucleic acids
- Patent Title (中): 单核糖体作为小干扰核酸的递送剂
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Application No.: US13496170Application Date: 2010-09-16
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Publication No.: US08916693B2Publication Date: 2014-12-23
- Inventor: Samuel P. McManus , Antoni Kozlowski , Patrick D. Youso
- Applicant: Samuel P. McManus , Antoni Kozlowski , Patrick D. Youso
- Applicant Address: US CA San Francisco
- Assignee: Nektar Therapeutics
- Current Assignee: Nektar Therapeutics
- Current Assignee Address: US CA San Francisco
- Agent Mark A. Wilson
- International Application: PCT/US2010/049179 WO 20100916
- International Announcement: WO2011/035065 WO 20110324
- Main IPC: C08B37/08
- IPC: C08B37/08 ; C07H21/02 ; A61K47/48
Abstract:
Conjugates are provided, an exemplary conjugating having a single water-soluble, non-peptidic polymer, such as a poly(ethylene oxide), attached to a chitosan. Complexes of small interfering nucleic acids formed with such conjugates as well as small interfering nucleic acids attached to such conjugates are also provided. Related methods, intermediates, and compositions are also provided.
Public/Granted literature
- US20120238735A1 Monoconjugated Chitosans as Delivery Agents for Small Interfering Nucleic Acids Public/Granted day:2012-09-20
Information query
