Invention Grant
- Patent Title: SNPs of apolipoprotein B and modulation of their expression
- Patent Title (中): 载脂蛋白B的单核苷酸多态性及其表达调控
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Application No.: US13016917Application Date: 2011-01-28
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Publication No.: US08916694B2Publication Date: 2014-12-23
- Inventor: Rosanne M. Crooke , Mark J. Graham , Steven Mah
- Applicant: Rosanne M. Crooke , Mark J. Graham , Steven Mah
- Applicant Address: US MA Cambridge
- Assignee: Genzyme Corporation
- Current Assignee: Genzyme Corporation
- Current Assignee Address: US MA Cambridge
- Agency: Jones Day
- Main IPC: C07H21/02
- IPC: C07H21/02 ; A01N43/04 ; C12Q1/68
Abstract:
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for diagnosis and treatment of diseases and conditions associated with expression of apolipoprotein B are provided.
Public/Granted literature
- US20110319469A1 SNPs of Apolipoprotein B and Modulation of Their Expression Public/Granted day:2011-12-29
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