The present invention discloses a liquid crystal panel, an OLED display panel, a glass substrate and the manufacturing method thereof, wherein, the liquid crystal panel comprises the opposite first substrate and second substrate. The first substrate and the second substrate respectively include a glass substrate. At least one of the first substrate and the second substrate includes an isolating layer, which is arranged on the inner surface of the glass substrate, for isolating the active alkali metal of the glass. Because the present invention uses the ordinary alkali free glass on the liquid crystal panel or the OLED panel as the glass substrate, and arranges an isolating layer on the glass substrate, the isolating layer can prevent the active alkali metal in the alkali free glass like active sodium ion, kalium ion etc. from reacting with other substances, thereby avoiding damages to devices in the panel resulting from the reaction between the active alkali metal like sodium ion or kalium ion and other substances, and increasing the lifetime of the Liquid Crystal Display (LCD) device and the OLED display device.